“Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner”. Damian E. Berardi*, Althea Bock-Hughes*, Alexander Terry, Lauren E Drake, Grazyna Bozek & Kay F Macleod. Science Adv. 8 (14): eabo2510 doi: 10.1126/sciadv.abo2510 (2022) *Co-first authors.

“ULK1 interacts with and phosphorylates BNIP3 to promote LC3 interaction, limit its proteasomal degradation and increase BNIP3-dependent mitophagy”. Logan P. Poole, Althea Bock-Hughes, Damian E. Berardi & Kay F. Macleod. Sci. Rep. 11(1): 20526. doi: 10.1038/s41598-021-00170-4 (2021).

“Autophagy in major human diseases”.
Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Kenneth Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Münz, Josef M. Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi and Federico Pietrocola. The EMBO J. 40(19): e108863. doi: 10.15252/embj.2021108863 (2021).

“BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver”. Maya Z. Springer, Logan P. Poole, Lauren E Drake, Althea Bock-Hughes, Michelle L. Boland, Alexandra G. Smith, John Hart, Aparajita H Chourasia, Ivan Liu, Grazyna Bozek & Kay F. Macleod. Autophagy 17 (11): 3530-3546 doi: 10.1080/15548627.2021.1877469 (2021).

“Mitophagy in Tumorigenesis and Metastasis”. Logan P. Poole & Kay F. Macleod.
Cell and Molecular Life Sciences 78 (8): 3817-3851 doi: 10.1007/s00018-021-03774-1 (2021).

“Guidelines for the use and interpretation of assays for monitoring autophagy (4th Edition)”.
Daniel J. Klionsky et al Autophagy 17 (1) 1 – 382 doi: 10.1080/15548627.2020.1797280 (2021)

“Mitophagy and mitochondrial dysfunction in cancer”.
Kay F. Macleod. Annual Reviews of Cancer Biology 4: pp 41 – 60 (2020).

“Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma”.
Adrian D Schubert, Esther C Broner, Nishant Agrawal, Nyall London, Alexander Pearson, Anuj Gupta, Neha Wali, Tanguy Y Seiwert, Sarah Wheelan, Mark Lingen, Kay Macleod, Hailey Allen, Aditi Chatterjee, Saloura Vassiliki, Daria Gaykalova, Mohammad O Hoque, David Sidransky, Karthik Suresh & Evgeny Izumchenko. Cancer Letters 471: 49-60 (2020).

“Nix-mediated mitophagy promotes pancreatic cancer.”
Timothy J. Humpton, Brinda Alagesan, Gina DeNicola, Dan Lu, Georgi N. Yordanov, Melissa A. Yao, Maya N. Zaatari, Youngkyu Park, Jeremy N. Skepper, Kay F. Macleod, Pedro A. Perez-Mancera, Michael P. Murphy, Gerard I. Evan, Karen H. Vousden & David A. Tuveson.
Cancer Discovery 9 (9) 1268-87 (2019).

“Autophagy, Cancer Stem Cells & Drug Resistance.”
Alexandra G. Smith & Kay F Macleod.
The Journal of Pathology 247:708-718 (2019). Featured on the journal cover.

“Autophagy & Cancer Cell Metabolism”. Cara M. Anderson & Kay F Macleod. In “Cellular Nutrient Utilization and Cancer” International Reviews in Cell & Molecular Biology vol. 347, pp145-190 (2019). Ed. Lorenzo Galluzi & David Montrose. Featured on the book cover.

“Dia1-dependent adhesions are required by epithelial tissues to initiate invasion”.
Tim B Fessenden, Yvonne Beckham, Gio Ramirez-San Juan, Mathew Perez-Neut, Aparajita H. Chourasia, Kay F. Macleod, Patrick W. Oakes & Margaret L. Gardel.
J. Cell Biol. 217 (4): 1485 – 1502 (2018). Featured on the journal cover.

“Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes”.
Rahul S. Kathayat, Yang Cao, Pablo D. Elvira, Patrick Sandoz, Maria-Eugenia Zaballa, Maya Z. Springer, Lauren E Drake, Kay F. Macleod, Gisou van der Goot & Bryan C. Dickinson.
Nat. Comm. 9 (1) 334 – 38 (2018).

“Functions of autophagy in the tumor microenvironment and cancer metastasis”.
Erin E. Mowers, Marina N. Sharifi & Kay F. Macleod.
The FEBs Journal 285 (10) 1751-1766 (2018) Featured on the journal cover.

“Autophagy gene Atg7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis”.
Lei Qiang, Ashley Sample, Christopher R. Shea, Keyoumars Soltani, Kay F. Macleod & Yu-Ying He. Autophagy 13 (12), 2086-2103 (2017).

“mTOR and HDAC inhibitors converge on the TXNIP/thioredoxin pathway to cause catastrophic oxidative stress and regression of RAS-driven tumors”.
Clare Malone, Chloe Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Kay F. Macleod, Ophelia Maertens & Karen Cichowski.
Cancer Discovery 7: 1450-1463 (2017).

“Expanding perspectives on the significance of mitophagy in cancer”.
Lauren E. Drake, Maya Z. Springer, Logan P. Poole, Casey J. Kim & Kay F Macleod.
Seminars in Cancer Biology 47: 110-147 (2017).

“Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth”.
Donghui Zhou, Maya Z Springer, David Xu, Degang Liu, Andy Hudmon, Kay F Macleod & Samy O Meroueh.
Bioorg. Med. Chem. 25 (12): 2995-3005 (2017).

“Autophagic degradation of focal adhesions underlies metastatic cancer dissemination”.
Marina N. Sharifi, Erin E. Mowers & Kay F. Macleod.
Molecular & Cellular Oncology 4 (2): e1198299 (2017).

“Autophagy in Cancer Metastasis”
Erin E. Mowers, Marina N. Sharifi & Kay F. Macleod.
Oncogene 36 (12): 1619-30 (2017).

“Mitophagy: Mechanisms and Role in Human Disease”.
Maya Z. Springer & Kay F. Macleod.
The Journal of Pathology 240 (3): 253-55 (2016).

“Novel Insights into how Autophagy Regulates Tumor Cell Motility”.
Erin E. Mowers, Marina N. Sharifi & Kay F. Macleod.
Autophagy 12 (9): 1679-80 (2016).

“Autophagy is required for focal adhesion disassembly, tumor cell motility and metastasis”
Marina N. Sharifi, Erin E Mowers, Christopher Collier, Hong Chen, Lauren Drake, Marta Zamora, Stephanie Mui, & Kay F. Macleod.
Cell Reports 15 (7): 1660-1672 (2016).

“Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Edition)”.
Daniel J. Klionsky et al
Autophagy 12 (1): 1-222 (2016).

“Tumor suppressor functions of BNIP3 and Mitophagy”
Aparajita H Chourasia & Kay F Macleod.
Autophagy 11 (9): 1-3 (2015).

“Mitophagy defects arising from BNIP3 loss promote mammary tumor progression to metastasis”
Aparajita H. Chourasia, Kristin Tracy, Casey Frankenberger, Michelle L. Boland, Marina Sharifi, Lauren Drake, Hong Chen, Joseph R Sachleben, John Asara, Jason Locasale, Gregory Karczmar & Kay F. Macleod.
EMBO Reports 16 (9): 1145-1163 (2015).

“Measuring autophagy in stressed cells” M.N. Sharifi, E.E. Mowers, L.E. Drake & K.F. Macleod. In “Stress Responses”, Methods in Molecular Biology, vol. 1292, chapter 10 (2015). Ed. Christine E Oslowski. ISBN 978-1-4939-2521-6. Humana Press, Springer Publishing Group.

“Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers” Xiaobing Fan, Kay Macleod, Devkumar Mustafi, Suzanne D Conzen, Erica Markiewicz, Marta Zamora, James Vosicky, Jeffrey Mueller & Gregory S Karczmar
PLoS ONE 10 (7): 1-14 (2015).

“Mitophagy & Cancer”
Aparajita H. Chourasia, Michelle L. Boland & Kay F. Macleod.
Cancer & Metabolism 3 (4): (2015).

“High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media”
Erica Markiewicz, Xiaobing Fan, Devkumar Mustafi, Marta Zamora, Brian Roman, Sonny A. Jansen, Kay Macleod, Suzanne D Conzen & Gregory S Karczmar.
Magn. Reson. Imaging 33 (1): 161-65 (2015).

“Mammary cancer initiation and progression studied with magnetic resonance imaging”
Xiaobing Fan, Devkumar Mustafi, Erica Markiewicz, Marta Zamora, James Vosicky, Abby Leinroth, Jeffrey Mueller, Kay Macleod, Suzanne D Conzen, Gregory S Karczmar.
Breast Cancer Research 16 (6): 495 (2014).

“Macro-Autophagy Deficiency promotes Resistance of squamous cell carcinomas of the head and neck to Phosphatidylinositol 3-Kinase and AKT Inhibitors”
Wen-Liang Kuo, Marina N. Sharifi, Mark Lingen, Theodore Karrison, Madhavi Nagilla, Omar Ahmed, Kay F. Macleod and Ezra E.W. Cohen
PLoS ONE 9: e90171 (2014).

“Tumor suppressor gene function in carcinoma-associated fibroblasts: From tumor cells via EMT and back again?”
Lauren E Drake & Kay F Macleod
J. Pathol., 232: 283-288 (2014).

“Mitochondrial dysfunction in cancer”
Michelle L Boland, Aparajita H Chourasia & Kay F. Macleod.
Frontiers in Oncology, 3: 292-320 (2013).

“BNIP3 regulates mitochondrial function and lipid metabolism in the liver.”
Danielle Glick, Wenshuo Zhang, Michelle Beaton, Glenn Marsboom, Michaela Gruber, M. Celeste Simon, John Hart, Gerald W. Dorn III, Matthew Brady & Kay F. Macleod.
Mol. Cell Biol. 32 (13): 2570-84 (2012).

“Guidelines for the use and interpretation of assays for monitoring autophagy.”
Daniel J. Klionsky et al
Autophagy 8 (4): 445-544 (2012).

“Developing an mTOR-inhibitor based combination cancer therapy“
Thomas De Raedt, Zandra Walton, Jessica Lucas, Danan Li, Yimei Chen, Ophelia Maertens, Seung Min Jeong, Roderick T. Bronson, Emmanuel Normant, Marcia C. Haigis, Brendan D. Manning, Kwok-Kin Wong, Kay F Macleod & Karen Cichowski.
Cancer Cell 20: 400-413 (2011).

“MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression”.
Szmulewitz, RZ., Clark, R, Lotan, T., Otto, K., Veneris, JT, Macleod, K., Rinker-Schaeffer, C.
Int. J. Cancer 130: 509-20 (2011).

“The RB tumor suppressor: a “gatekeeper” to hormone-independence in prostate cancer?”
Kay F. Macleod:
J. Clin. Investig. 120 (12): 4179-82 (2010).

“Autophagy: Cellular & Molecular Mechanisms”.
Danielle Glick, Sandra Barth & Kay F. Macleod
J. Pathol. 221 (1): 3-12 (2010).

“Autophagy: Assays and Artifacts.”
Sandra Barth, Danielle Glick & Kay F. Macleod
J. Pathol. 221 (2): 117-124 (2010).

“Elevated Parp sensitizes Rb deficient cells to DNA damage-induced necrosis.”
Huiping Liu, James R. Knabb, Benjamin T. Spike & Kay F. Macleod
Mol. Cancer Res. 7: 1099-1109 (2009).

“New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells”
JL. Taylor, RZ Szmulewitz, T Lotan, J Hickson, DV Griend, SD Yamada, K Macleod, C Rinker-Schaeffer. Cancer Lett. 272: 12-22 (2008).

“c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase-4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation.”
Tamara Lotan, Jonathan Hickson, Jeffery Souris, Dehzeng Huo, Jennifer Taylor, Terry Li, Kristen Otto, Seiko Diane Yamada, Kay Macleod & Carrie W. Rinker-Schaeffer.
Cancer Research 68: 2166-75 (2008).

“Functions of the retinoblastoma tumor suppressor in modulating oxidative stress responses in the hematopoietic system.”
Kay F. Macleod
Nature Reviews in Cancer 8: 769-81 (2008).

“Guidelines for Monitoring Autophagy in Higher Eukaryotes.“
Daniel J. Klionsky et al
Autophagy 4 (2): 151-175 (2008).

“De-regulated E2f-2 activity drives deregulated cell cycle and maturation defects in Rb null erythroblasts.” Dirlam, A. Spike, B.T. & Macleod, KF
Mol.Cell Biol. 27 (24): 8713-28 (2007).

“Effects of hypoxia on heterotypic macrophage interactions.”
Benjamin T Spike & Kay F. Macleod
Cell Cycle 6 (21): 2620-4 (2007).

“Hypoxic stress underlies defects in erythroblast islands in the Rb null mouse.“
Spike, BT, Dibling BC & Macleod, KF.
Blood 110: 2173-81 (2007).

“Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3.”
Kristin Tracy & Kay F. Macleod.
Autophagy 3 (6): 616-619 (2007).

“BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.”
Kristin Tracy, Benjamin C. Dibling, Benjamin T. Spike, James Knabb, Paul Schumacker & Macleod KF. Mol. Cell Biol. 27: 6229-42 (2007).

“Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.”
Abhinav Diwan, Andrew G Koesters, Amy M Odley, Suvarnamala Pushkaran, Christopher P Baines, Benjamin T Spike, Diedre Daria, Anil G Jegga, Hartmut Geiger, Bruce J Aronow, Jeffrey D Molkentin, Kay F Macleod, Theodosia A Kalfa, Gerald W Dorn II
Proc.Natl.Acad.Sci.USA 104: 6794-9 (2007).

“The Retinoblastoma tumor suppressor.” A, Dirlam & K. F. Macleod In “The Cancer Handbook”. Second edition. Chapter 24. Edited by Malcolm R Alison. John Wiley & Sons Ltd (2007).

“The Rb tumor suppressor in stress responses and hematopoietic homeostasis.”
Spike, BT & KF Macleod
Cell Cycle 4: e181-184 (2005).

“A novel form of pRb expressed during normal myelopoiesis and in tumor associated macrophages.”
Liu, H., Thompson, A. & Macleod K.F.
Cell Proliferation 38:13-24 (2005).

“The Rb tumor suppressor is required for stress erythropoiesis.”
Spike, B.T., Dirlam, A., Dibling, B., Marvin, J., Williams, B.O., Jacks, T. & Macleod, K.F.
The EMBO Journal. 23: 4319-29 (2004).

“Novel functions of the RB tumor suppressor”
Huiping Liu, Ben Dibling, Ben Spike, Alexandra Dirlam & Kay F. Macleod
Current Opinions in Genetics & Development 14: 55-64 (2004).

“Cell-autonomous and non-cell autonomous functions of the Rb tumor suppressor in developing central nervous system”
Marta Lipinski, Kay F. Macleod, Bart O.Williams, Denise Crowley, Tara L. Mullaney & Tyler Jacks.
The EMBO Journal 20: 3402-3413 (2001).

“Tumour suppressor genes.”
K.Macleod
Current Opinions in Genetics & Development. 10: 81-93 (2000).

“Rb and E2f-1 in Mouse Development and Tumourigenesis”
K.F.Macleod
Current Opinions in Genetics & Development. 9: 30-37 (1999).

“Insights into Cancer from Transgenic Mouse Models”
K.F.Macleod & T. Jacks
The Journal of Pathology 187: 43-60 (1999).

“Mutation of E2f-1 suppresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos”
Tsai, K.Y., Hu, Y., Macleod, K.F., Crowley, D., Yamasaki, L. & T. Jacks
Molecular Cell 2: 283-292 (1998).

“Loss of Rb activates both p53-dependent and -independent cell death pathways in the developing mouse nervous system.”
K. F. Macleod, Y. Hu & T. Jacks.
The EMBO Journal 15: 6178-6188 (1996).

“p53-Dependent and independent expression of p21 during cell growth, differentiation and DNA damage.” K. F. Macleod, N. Sherry, G. Hannon, D. Beach, T. Tokino, K, Kinzler, B. Vogelstein, T. Jacks.
Genes & Development 9: 935-944 (1995).

“Pax-QNR/Pax-6, a paired- and homeobox-containing protein, recognizes Ets binding sites and can alter the transactivating properties of Ets transcription factors.”
S. Plaza, D. Grevin, K. Macleod, D. Stehelin, S. Saule.
Gene Expression 4: 43-53 (1994).

“Transcription Factors of the Ets Family: The Example of c-ets-1.” K. Macleod, D. Leprince, D. Stehelin. In “Regulation of Gene Expression in Animal Viruses”, pages 93-105. Plenum Publishing Corporation (1993).

“The Ets Gene Family.”
K. Macleod, D. Leprince, D. Stehelin.
Trends in Biochemical Sciences 17: 251-256 (1992).

“Derepression of Mouse Bmajor Globin Gene Transcription during Erythroid Differentiation.
Kay Macleod and Mark Plumb.
Molecular and Cellular Biology 11: 4324-4332 (1991).

“The GATAAG motif specifies erythroid specificity in gene regulatory elements by interacting with an erythroid-specific nuclear protein.” M. Plumb, K. Macleod, S. Lowe, M. Walker, J. Frampton, G. Goodwin, P.R. Harrison. In “Molecular biology of Haematopoiesis” (Eds. N.G. Abraham, G. Konmalinka, L. Sachs, C.J. Wideman). Intercept Publishing Co. Chapter 27 (1990).

“Regulation of Erythroid Gene Expression.”
P.R. Harrison, M. Plumb, J. Frampton, B. Thiele, K. Macleod, J. Chester, I. Chambers, J. Fleming, J. O’Prey, M. Walker, H. Wainwright, S. Lowe, S. Janetzski.
Biomed.Biochim.Acta 49: 5-10 (1990).

“GATAAG: a cis control region binding an erythroid specific nuclear factor with a role in globin and non-globin gene expression.”
M. Plumb, J. Frampton, H. Wainwright, M. Walker, K. Macleod, G. Goodwin, P.R. Harrison.
Nucleic Acids Research 17: 73-92 (1989).

“Regulation of Erythroid Cell-specific Gene Expression during Erythropoiesis.”
P.R. Harrison, M. Plumb, J. Frampton, D. Llewelyn, J. Chester, I. Chambers, K.Macleod, J. Fleming, J. O’Prey, M. Walker, H. Wainwright, I. Anton.
British Journal of Cancer 58: 46-57 (1988).

“Cis and trans Control of Erythroid Cell-specific Gene Expression during Erythropoiesis.”
P.R. Harrison, M. Plumb, J. Frampton, I. Chambers, D. Llewelyn, J. Chester, K.Macleod, J. Fleming, J. O’Prey, M. Walker, H. Wainwright.
Journal of Cell Science 10: 145-155 (1988).

“Characterization, evolutionary relationships, and chromosome location of processed mouse HPRT pseudogene.”
M. Isamat, KF. Macleod, A. King, C. McEwan, DW Melton.
Somat. Cell Mol. Genet. 14: 359-69 (1988).