Our work showing a role for BNIP3 in suppressing hepatocellular carcinoma (HCC) via turnover of lipid with mitochondria is published in Science Advances. Featured on the journal’s website and on Biomedical picture of the day (http://bpod.mrc.ac.uk/archive/2022/12/3)! Liver cancer rates are rising at an alarming rate in western society due to elevated obesity and sedentary lifestyles and our work aims to understand how BNIP3 clears lipid from liver to determine whether we can leverage this knowledge to treat fatty liver disease and HCC.